Purpose:
The University of Utah Comparative Genomic Hybridization Microarray Laboratory was one of the first US laboratories to offer comparative genomic hybridisation (CGH) microarray testing using a commercial platform in a clinical setting. Results for 1076 patients (1598 chips) are presented.
Methods:
The Spectral Genomics/PerkinElmer Constitutional ChipTM (targeted array), SpectralChip 2600TM (whole genome array) and a "Combo" chip (both arrays run simultaneously) were the tests offered. Abnormal results were confirmed by an alternative method, most often fluorescence in situ hybridisation.
Results:
In 669 cases with known normal cytogenetics, an abnormal d[...]